Editorial: developing a stimulation test to identify FGF19 deficiency in bile acid diarrhoea

Managing bile acid diarrhoea.

Bowel symptoms including diarrhoea can be produced when excess bile acids (BA) are present in the colon. This condition, known as bile acid or bile salt malabsorption, has been under recognized, as the best diagnostic method, the (75)Se-homocholic acid taurine (SeHCAT) test, is not available in many countries and is not fully utilized in others. Reduced SeHCAT retention establishes that this is...

Bile Acid Induced Diarrhoea

Bile Acid Malabsorption/Diarrhoea

Bile acid malabsorption leads to chronic watery, non-bloody diarrhoea. Many patients present with symptoms suggestive of IBS. Idiopathic BAM (no obvious cause) occurs in both men and women, mostly between the ages of 30 and 70. There is often a long history of diarrhoea at the time of diagnosis, sometimes lasting longer than 10 years. The diarrhoea is continuous or intermittent; nocturnal diarr...

Application of a Novel Tool for Diagnosing Bile Acid Diarrhoea

Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs. ulcerative colitis and healthy controls. A total of 110 patients were recruited; 23 with BAD, 42 with ulcerative colitis (UC) and 45 controls...

Altered bile in diabetic diarrhoea.

The size and composition of the bile-salt pools in a group of diabetics with neuropathy but no diarrhoea and a group with "diabetic diarrhoea" were compared with those in a group of stable, uncomplicated diabetics. The diabetics with neuropathy had significantly more dihydroxy bile salts, a larger bile-salt pool, and a higher faecal excretion of bile than the controls. The diabetics with diarrh...